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As weight decreases, your metabolism and calorie needs drop, which can slow or stop fat loss if intake isn’t adjusted

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In obesity, the gut microbiota is dysbiotic, and this dysbiosis is associated with blunted endogenous GLP-1 secretion, partly through downregulation of GLP-1R and nNOS expression in the enteric nervous system (Inagaki & Yamane, 2017)

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